Sertoli-Leydig Cell Tumor of the Ovary in a Postmenopausal Woman

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Sertoli-Leydig Cell Tumor of the Ovary in a Postmenopausal Woman

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Sertoli-Leydig cell tumor of the ovary (as called Androblastoma) is a rare entity composed of variable proportions of Sertoli cells, Leydig cells, and sometimes primitive gonadal stroma and heterologous elements [1]. НLs lesion accounts for less than 0.5% of all ovary neoplasms, but it represents the most common androgenic functioning tumor, due to it can secrete testosterone, and less frequently human chorionic gonadotropin (HCG) and α-fetoprotein (AFP) [2,3]. Sertoli-Leydig cell tumor of the ovary aوٴects predominantly young women, 40-60% of whom associate signs of virilization [1]. We present a case of a Sertoli-Leydig cell tumor of the ovary in a postmenopausal woman without any evident signs of virilization or other symptoms.

Sertoli-Leydig cell tumor of the ovary represents less than 0.5% of all ovary neoplasms. It is a tumor that affects predominantly young woman, who most of the times associate signs of virilization. It has recently been associated with mutations in DICER1. In this report, we describe a case of Sertoli-Leydig cell tumor in an asymptomatic 61- year-oldwoman who underwent a laparoscopic bilateral anexectomy for a heterogenous cystic lesion found in her left ovary. The microscopic examination of the lesion, showed a solid-cystic tumoral proliferation in the region identified as ovarian hilum, formed by two distinct and intermixed cell populations (Leydig cells and Sertoli cells). The prognosis of this kind of tumor is usually good, unless it shows poor differentiation and/or heterologous elements or retiforme pattern. So, the recommended treatment of these tumors, is a conservative approach. In our case, the anexectomy was performed by expressed desire of the patient.

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