Psoriasis is a chronically relapsing skin inflammation affecting about 2% the population worldwide. Plaque psoriasis, also known as psoriasis vulgaris, is the most common form of the disease. However there is now accumulating evidence of important systemic manifestations of psoriasis including cardiovascular disorders and metabolic syndrome. About 30% of patients also develop psoriatic arthritis (PsA), which manifests as an inflammation of the synovium, entheses and spine. Therefore, the term Psoriatic Disease has been recently introduced to encompass the different clinical manifestations of this disorder.

At the skin level, psoriasis pathogenesis involves a complex interplay between T cells, dendritic cells and keratinocytes in which autoreactive CD8+ T lymphocytes have been suggested to be involved in the early phase, whereas IL-17-producing T cells play a central role in the amplification phase by enhancing the inflammatory response of keratinocytes and creating a positive feedback loop around the IL-23/IL-17 axis. A marked enhancement of IFNγ and Th1 T cell infiltration also occurs in psoriatic plaques, although the specific role of this infiltration in the pathogenesis of psoriasis is currently unclear.

A standard EDITORIAL TRACKING SYSTEM is utilized for manuscript submission, review, editorial processing and tracking which can be securely accessed by the authors, reviewers and editors for monitoring and tracking the article processing. Manuscripts can be uploaded online at Editorial Tracking System (https://www.longdom.org/submissions/hair-therapy-transplantation.html) or forwarded to the Editorial Office at hairtherapy@emedscholar.com

Media Contact:               

Sandra Jones

Journal Manager

Hair Therapy and Transplantation

Email: hairtherapy@emedscholar.com

Psoriasis is a chronically relapsing skin inflammation affecting about 2% the population worldwide. Plaque psoriasis, also known as psoriasis vulgaris, is the most common form of the disease. However there is now accumulating evidence of important systemic manifestations of psoriasis including cardiovascular disorders and metabolic syndrome. About 30% of patients also develop psoriatic arthritis (PsA), which manifests as an inflammation of the synovium, entheses and spine. Therefore, the term Psoriatic Disease has been recently introduced to encompass the different clinical manifestations of this disorder.

At the skin level, psoriasis pathogenesis involves a complex interplay between T cells, dendritic cells and keratinocytes in which autoreactive CD8+ T lymphocytes have been suggested to be involved in the early phase, whereas IL-17-producing T cells play a central role in the amplification phase by enhancing the inflammatory response of keratinocytes and creating a positive feedback loop around the IL-23/IL-17 axis. A marked enhancement of IFNγ and Th1 T cell infiltration also occurs in psoriatic plaques, although the specific role of this infiltration in the pathogenesis of psoriasis is currently unclear.

A standard EDITORIAL TRACKING SYSTEM is utilized for manuscript submission, review, editorial processing and tracking which can be securely accessed by the authors, reviewers and editors for monitoring and tracking the article processing. Manuscripts can be uploaded online at Editorial Tracking System (https://www.longdom.org/submissions/hair-therapy-transplantation.html) or forwarded to the Editorial Office at hairtherapy@emedscholar.com

Media Contact:               

Sandra Jones

Journal Manager

Hair Therapy and Transplantation

Email: hairtherapy@emedscholar.com