Clinical Toxicology offers rapid peer review process for authors

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Journal of Clinical Toxicology - Open Access using online manuscript submission, review and tracking systems of OMICS Group for quality and quick review processing.OMICS Group is using Online Review and Editorial Tracking Systems for quality review process. Editorial Tracking System is an online submission and review system, where authors can submit manuscripts and track their progress. Reviewers can download manuscripts and submit their opinions. Editors can manage the whole submission/review/revise/publish process. Publishers can see what manuscripts are in the pipeline awaiting publication. E-mail is sent automatically to concerned persons when significant events occur.

 

Submit manuscript as an e-mail attachment to the Editorial Office at https://www.longdom.org/submissions/clinical-toxicology.html or toxicology@eclinicalsci.com and toxi@eclinicalsci.com

 

Manuscripts number will be provided to the corresponding author within 72 hours for the respective manuscript submitted.

 

  • 21 day rapid review process with international peer-review standards.
  • Timeline of processing from Submission to Publication is 45 days.
  • Manuscript will be published within 7days of acceptance.

Current practices in drug development have led to therapeutic compounds being approved for widespread use in humans, only to be later withdrawn due to unanticipated toxicity. These occurrences are largely the result of erroneous data generated by in vivo and in vitro preclinical models that do not accurately recapitulate human physiology. Herein, a human primary cell- and stem cell-derived 3D organoid technology is employed to screen a panel of drugs that were recalled from market by the FDA. The platform is comprised of multiple tissue organoid types that remain viable for at least 28 days, in vitro. For many of these compounds, the 3D organoid system was able to demonstrate toxicity

Furthermore, organoids exposed to non-toxic compounds remained viable at clinically relevant doses. Additional experiments were performed on integrated multi-organoid systems containing liver, cardiac, lung, vascular, testis, colon, and brain. These integrated systems proved to maintain viability and expressed functional biomarkers, long-term. Examples are provided that demonstrate how multi-organoid ‘body-on-a-chip’ systems may be used to model the interdependent metabolism and downstream effects of drugs across multiple tissues in a single platform. Such 3D in vitro systems represent a more physiologically relevant model for drug screening and will likely reduce the cost and failure rate associated with the approval of new drugs

In order to reduce delays, authors should adhere to the level, length and format of the Longdom Publishing Journals at every stage of processing right from manuscript submission to each revision stage. Submitted articles should have a 300 words summary/abstract, separate from the main text. The summary should provide a brief account of the work by clearly stating the purpose of the study and the methodology adopted, highlighting major findings briefly. The text may contain a few short subheadings of no more than 40 characters each.

Media contact:

Larry Tyler

Managing Editor

Journal of Clinical Toxicology

Media contact: jct@peerjournal.org

Whatsapp: +1-504-608-2390